Panic attacks can present with alarming physical symptoms that often mimic serious cardiac or respiratory conditions, making it crucial for GPs to quickly distinguish benign panic episodes from medical emergencies. This practical guide summarises the evidence-backed steps for triaging, stabilising and managing panic attacks in general practice, including the importance of ruling out red flags, educating patients about the body’s fight‑or‑flight response, and using slow diaphragmatic breathing and brief cognitive techniques to reduce distress. It highlights why CBT is the first‑line intervention, explains when to consider pharmacotherapy, and outlines clear referral pathways to clinical psychology, ensuring patients receive timely, appropriate care while avoiding unnecessary emergency presentations.